Teiko.bio

Unlock insights for autoimmune therapies

With easily accessible blood samples

Deep immune profiling paired with a robust analysis platform can unlock actionable insights for therapy development. This data is now measurable in peripheral blood through the TokuProfile.

Understanding how a therapy works at a cellular level can improve trial design and accelerate candidates to approval.

Immune monitoring has emerged as an essential tool for the development of autoimmune therapies.

Paper

Mass cytometry reveals systemic and local immune signatures that distinguish inflammatory bowel diseases

Paper

Candidate Markers for Stratification and Classification in Rheumatoid Arthritis

Paper

Cytometry by time of flight identifies distinct signatures in patients with systemic sclerosis, systemic lupus erythematosus and Sjögrens syndrome

Map Characteristics of response

Map Characteristics of response

Deep immune profiling enables more complete understanding and informed decision making

TokuProfile identifies:

  • Abundance of different immune cell types
  • Activation scores for each immune cell type
  • Rational targets for suggested combination
  • Immune features associated with response

Accelerate the Pipeline

  • Discovery Mechanism of action
    Mechanism of resistance
    Rational combinations
  • Phase I/II ID response characteristics
    Novel pathway identification
    Rational combinations
  • Phase III Likelihood for Response
    Likelihood for Adverse Events

Novel Pathway Identification – Cancer Example

A TokuProfile™ Can Reveal Unique Insights

Before Teiko.bio
Before Teiko.bio

The assumption is that CD8 T-cells need to be targeted directly. However, this leads to therapy failure.

Discovery
Discovery

Profiling reveals that even though CD8 T-cells appear suppressed, the actual issue is with the Dendritic Cells not being active.

After Teko.bio
After Teko.bio

Anti CD40 Therapy Activates Dendritic Cells to create therapy success.

Pre-clinical Discovery

Pre-clinical Discovery

 

  • Syngeneic Mouse Models
  • Xenograft Mouse Models Identify and understand:
    • Mechanism of action
    • Mechanisms of resistance
    • Rational combinations