Map entire immune responsesFrom easily accessible blood
Acute immune responses to infection rely on dramatic changes in the immune cell composition. This action is now measurable in peripheral blood through the TokuProfile.
Understanding the natural response to an infectious disease and how a therapy works at a cellular level can improve trial design and accelerate candidates to approval.
Immune profiling by mass cytometry is becoming an essential tool in vaccine development.
A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory
High-dimensional immune profiling by mass cytometry revealed immunosuppression and dysfunction of immunity in COVID-19 patients
Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19
Accelerate the Pipeline
- Discovery Mechanism of action
Mechanism of resistance
- Phase I/II ID response characteristics
Novel pathway identification
- Phase III Likelihood for Response
Likelihood for Adverse Events
Novel Pathway Identification – Cancer Example
A TokuProfile™ Can Reveal Unique Insights
The assumption is that CD8 T-cells need to be targeted directly. However, this leads to therapy failure.
Profiling reveals that even though CD8 T-cells appear suppressed, the actual issue is with the Dendritic Cells not being active.
Anti CD40 Therapy Activates Dendritic Cells to create therapy success.