Teiko.bio

Map entire immune responses

From easily accessible blood

Acute immune responses to infection rely on dramatic changes in the immune cell composition. This action is now measurable in peripheral blood through the TokuProfile.

Understanding the natural response to an infectious disease and how a therapy works at a cellular level can improve trial design and accelerate candidates to approval.

Immune profiling by mass cytometry is becoming an essential tool in vaccine development.

Paper

A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory

Paper

High-dimensional immune profiling by mass cytometry revealed immunosuppression and dysfunction of immunity in COVID-19 patients

Paper

Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19

Map Characteristics of Response

Map Characteristics of Response

Deep immune profiling enables more complete understanding and informed decision making

TokuProfile identifies:

  • Abundance of different immune cell types
  • Activation scores for each immune cell type
  • Rational targets for suggested combination
  • Immune features associated with response

Accelerate the Pipeline

  • Discovery Mechanism of action
    Mechanism of resistance
    Rational combinations
  • Phase I/II ID response characteristics
    Novel pathway identification
    Rational combinations
  • Phase III Likelihood for Response
    Likelihood for Adverse Events

Novel Pathway Identification – Cancer Example

A TokuProfileā„¢ Can Reveal Unique Insights

Before Teiko.bio
Before Teiko.bio

The assumption is that CD8 T-cells need to be targeted directly. However, this leads to therapy failure.

Discovery
Discovery

Profiling reveals that even though CD8 T-cells appear suppressed, the actual issue is with the Dendritic Cells not being active.

After Teko.bio
After Teko.bio

Anti CD40 Therapy Activates Dendritic Cells to create therapy success.

Pre-Clinical Discovery

Pre-Clinical Discovery

  • Syngeneic Mouse Models

    Applicable for most vaccine development

  • Identify and understand:

    • Mechanism of action
    • Mechanisms of resistance
    • Rational combinations