Teiko.bio

Senior Bioinformatics Engineer

We started Teiko Bio to use immune insights to help deliver life changing therapies to those who need them most.  Today, Teiko delivers on its mission by supporting therapy development and informing clinical decision making.  By using cutting edge mass cytometry, Teiko’s leading assay, the TokuProfile, maps characteristics of response, accelerates clinical pipeline candidates, and supports identification of novel discoveries.

About you:

  • Familiar with single cell or genomics data analysis
  • Motivated to help breakthrough therapies reach patients
  • Excited to tackle ground-floor challenges and work with seasoned scientists and proven entrepreneurs

Responsibilities

  • Develop sample-to-answer workflow
  • Develop and implement a centralized data management solution
  • Build industrial, production-quality pipeline for data processing and analysis of high-dimensional cytometry data
  • Design and implement visualizations and reports for high-dimensional cytometry data
  • Develop and implement quality control automation
  • Build production-quality client-facing web application
  • Work with scientists to implement machine learning algorithms
  • Contribute to product development and customer success

Experience

  • No degree required, but proficiency usually demonstrated by getting a Bachelor/Master’s in computer science or computer engineering, or PhD in bioinformatics, computational biology, immunology, or related discipline. If you don’t have an advanced degree, your resume should demonstrate a mastery of concepts.
  • Proficiency in commonly used languages: Python, R, etc.
  • 3+ years’ experience in building production-level software
  • Highly skilled in data management, including relational database
  • Demonstrated experience with building customer-facing web applications
  • Experience with cloud computing platforms (AWS, GCP, Azure)
  • Experience with best practices in software development, including readable code, version control, unit tests, continuous integration
  • Experience with Lab Information Management System (LIMS), such as Benchling (preferred but not required)
  • Familiarity with large scale “omics” datasets: genomics, cytometry, etc.
  • Demonstrated experience with the analysis of single-cell data
  • Practical, working knowledge of modern bioinformatics tools

Senior Research Associate – Cytometry

Job Summary

We started Teiko Bio to use immune insights to help deliver life changing therapies to those who need them most.  Today, Teiko delivers on its mission by supporting therapy development and informing clinical decision making.  By using cutting edge mass cytometry, Teiko’s leading assay, the TokuProfile, maps characteristics of response, accelerates clinical pipeline candidates, and supports identification of novel discoveries.

About you:

  • Familiar with single cell or genomics assays
  • Motivated to help breakthrough therapies reach patients
  • Excited to tackle ground-floor challenges and work with seasoned scientists and proven entrepreneurs

The Senior Research Associate will be performing immunophenotyping with human specimens. Responsibilities include the operation, calibration and maintenance of cytometer and related equipment, data acquisition, and documentation of results. The Senior Research Associate will participate in the development and validation of new procedures and tests in the laboratory located in Salt Lake City, UT. This position will report to the Director of Laboratory Operations. 

Job Description

  • Preparation and immunophenotyping of human cellular products for use in research protocols according to lab procedures.
  • Data acquisition, analysis, documentation and maintenance of test results according to lab procedures.
  • Perform tests using SOP involving multiple methodologies. These may include automated, semi-automated or manual technologies.
  • Operation and maintenance of cytometer-related computer hardware and software.
  • Evaluates/troubleshoots problems related to sample analysis and preparation. 
  • Communicates outcomes to appropriate supervisors.
  • Ensures clear lines of communication and expectations throughout the organization.
  • Fosters a continuous improvement mindset within the organization, ensuring continued focus on capacity planning and optimized workflow.

Education and Experience

  • A formal degree isn’t required, but you do need to show mastery of biological concepts. That mastery is usually shown by
    • BS/BA in a Biological Science or related field plus three years laboratory experience, or a Masters in a Biological Science or related field plus 1 year laboratory experience.
  • Experience operating flow cytometers and/or Fluorescence-Activated Cell Sorters (FACS) preferred.
  • Experience with data acquisition, data analysis, data presentation and documentation preferred.
  • Biological Research experience, Biosafety Level (BSL) 2 cell culture lab experience preferred.
  • Position requires an ongoing commitment to upgrading of job skills. Must be able to work closely with others & possess solid interpersonal & communication skills.
  • Capable of working in a fast-paced environment; effective in a diverse work group; willing to work in a rapidly changing work unit.
  • Able to work independently on off-shifts, capable of handling stress of producing accurate results under time constraints; willing to accommodate schedule adjustments, as well as off-shift and weekend assignments as workload dictates.
  • The ability to be flexible & adaptable to changing technology.
  • Must be able to work independently.
  • General lab skills and knowledge of lab safety.

Research Associate – Cytometry

Job Summary

We started Teiko Bio to use immune insights to help deliver life changing therapies to those who need them most.  Today, Teiko delivers on its mission by supporting therapy development and informing clinical decision making.  By using cutting edge mass cytometry, Teiko’s leading assay, the TokuProfile, maps characteristics of response, accelerates clinical pipeline candidates, and supports identification of novel discoveries.

About you:

  • Familiar with single cell or genomics assays
  • Motivated to help breakthrough therapies reach patients
  • Excited to tackle ground-floor challenges and work with seasoned scientists and proven entrepreneurs

The Research Associate will be performing immunophenotyping with human and preclinical specimens. Responsibilities include the operation, calibration and maintenance of cytometer and related equipment, data acquisition, and documentation of results. The Research Associate will participate in the development and validation of new procedures and tests in the laboratory located in Salt Lake City, UT. This position will report to the Director of Laboratory Operations.

Job Description

  • Perform administrative tasks such as managing reagent inventory, test subject records, and scheduling equipment maintenance. 
  • Preparation and maintenance of cytometry-related reagents.
  • Perform tests using SOP involving multiple methodologies. These may include automated, semi-automated or manual technologies.
  • Perform preventive and corrective maintenance of equipment and instrumentation.
  • Operation and maintenance of cytometer-related computer hardware and software.
  • Communicates outcomes to appropriate supervisors.
  • Other general administrative duties as required.
  • Ensures clear lines of communication and expectations throughout the organization.
  • Fosters a continuous improvement mindset within the organization, ensuring continued focus on capacity planning and optimized workflow.

Education and Experience

  • A formal degree isn’t required, but you do need to show mastery of biological concepts. That mastery is usually shown by a BS/BA in a Biological Science or related field plus 1 year laboratory experience.
  • Proficiency in Microsoft Office programs and basic statistical methods.
  • Experience with data acquisition, data analysis, data presentation and documentation preferred.
  • Position requires an ongoing commitment to upgrading of job skills. Must be able to work closely with others & possess solid interpersonal & communication skills.
  • Capable of working in a fast-paced environment; effective in a diverse work group; willing to work in a rapidly changing work unit.
  • The ability to be flexible & adaptable to changing technology.
  • Must be able to work independently.
  • General lab skills and knowledge of lab safety.

Scientist – Cytometry

Job Summary

We started Teiko Bio to use immune insights to help deliver life changing therapies to those who need them most.  Today, Teiko delivers on its mission by supporting therapy development and informing clinical decision making.  By using cutting edge mass cytometry, Teiko’s leading test, the TokuProfile, helps drugs companies find how their drugs are affecting the immune system.

About you:

  • Familiar with single cell and high-parameter flow cytometry assays
  • Motivated to help breakthrough therapies reach patients
  • Excited to tackle ground-floor challenges and work with seasoned scientists and proven entrepreneurs

The Scientist will be performing immunophenotyping with human and animal specimens. Responsibilities include the design, development, execution and validation of cytometry assays; data acquisition, analysis and documentation of results. The Scientist will participate in the development of new procedures and tests in the laboratory located in Salt Lake City, UT. This position will report to the VP of Laboratory Operations. 

Job Description

  • You’ll be asked to:
    • Independently plan and execute cytometry assays
    • Process specimens from diverse tissue origins [i.e. tumor], and use flow- and mass- cytometry instruments to provide data on target cellular level, cell phenotype, cellular signaling and downstream functional response.  The result of these initiatives will enable project milestones and influence portfolio decisions for our customers. 
    • Drive technology innovation, review literature, evaluate new methodologies and instrumentation.  All of these initiatives will help advance single-cell analysis. 
    • Critically analyze experimental data and communicate results across teams with diverse scientific and technical backgrounds 
    • Adhere to scientific rigor and standards including electronic record keeping, data peer-review, quality control and reporting. 
    • Present complex data internally at team meetings and externally at scientific venues and conferences.
    • Able to work swing shifts during periods of high demand (including afternoon to evening shifts) 

Education and Experience

  • No degree required, but Proficiency usually demonstrated by getting a PhD in immunology, or related discipline.
  • However, if you don’t have an advanced degree, your resume should demonstrate a mastery of concepts OR research experience in Immunology, Immuno-oncology, or a related field in an academic or biopharmaceutical setting 
  • Experience with multi-color flow cytometry is required; experience in spectral flow-cytometry or CyTOF is preferred 
  • Experience with protein biochemistry techniques is required 
  • Proficiency in Biosafety Level (BSL) 2 cell culture techniques. 
  • Demonstrated track record of independent research and scientific productivity, such as first-author publications in peer review journals. 
  • Be a self-starter, able to handle multiple projects concurrently 
  • Experience working well with teams, adapting to rapidly changing customer needs, and delivering quality work on time

Melanoma Clinical Consultant

We started Teiko Bio to use immune insights to help deliver life-changing therapies to those who need them most.  Today, Teiko delivers on its mission by informing clinical decision-making.  By using cutting-edge high-dimensional cytometry, Teiko’s leading assay, the TokuProfile, looks at the immune system of your patients, and predicts which ones are likely to do well. 

Teiko is looking for clinical specialists in melanoma to consult on the development of the TokuProfile for use by oncologists.  Consultation can be on an ad-hoc basis or as part of our formal scientific advisory board.

About you:

  • Have a clinical and practical understanding of melanoma treatments and tests used by physicians 
  • Detail-oriented: understand what makes a good product for physicians
  • Motivated to help breakthrough therapies reach patients
  • Excited to tackle ground-floor challenges and work with seasoned scientists and proven entrepreneurs

Responsibilities:

You would consult with the Teiko.bio medical strategy team on the following topics:

  • Areas of greatest clinical need in daily practice
  • Immune signatures or clinical evidence that would change prescribing behavior
  • Clinical use cases
  • Test outcomes desired by physicians, e.g. projected overall survival, likelihood to respond to treatment, etc.
  • Test report requirements from a clinical perspective, e.g. content, main output and turnaround time
  • Fit of test into NCCN guidelines for melanoma
  • Most appropriate clinical reimbursement strategy 

Qualifications:

  • Interest to help make products successful in clinical practice
  • Medical Degree with more than 3 years of clinical experience
  • Board-certified or board-eligible in medical or hematological oncology 
  • Spend more than 75% of working time on seeing oncology patients
  • See more than 10 unique melanoma patients on a weekly basis

Computational Biologist

We started Teiko Bio to use immune insights to help deliver life changing therapies to those who need them most. Today, Teiko delivers on its mission by supporting therapy development and informing clinical decision making. By using cutting edge mass cytometry, Teiko’s leading assay, the TokuProfile, maps characteristics of response, accelerates clinical pipeline candidates, and supports identification of novel discoveries.

About you:

  • Familiar with single cell or genomics data analysis
  • Motivated to help breakthrough therapies reach patients
  • Excited to tackle ground-floor challenges and work with seasoned scientists and proven entrepreneurs

Responsibilities

  • Develop sample-to-answer workflow
  • Build and test processing pipeline for specimens
  • Design and implement visualizations for high-dimensional cytometry data
  • Work with scientists to implement machine learning algorithms
  • Contribute to product development and customer success

Experience

  • No degree required, but proficiency usually demonstrated by getting a PhD in bioinformatics, computational biology, immunology, or related discipline. However, if you don’t have an advanced degree, your resume should demonstrate a mastery of concepts.
  • Practical, working knowledge of modern bioinformatics tools
  • Proficiency in commonly-used languages: Python, R, etc.
  • Demonstrated ability to write re-usable “library” code, strongly preferred
  • 2 – 5 years experience in production-level environment
  • Familiarity with large scale “omics” datasets: genomics, cytometry, etc.
  • Demonstrated experience with the analysis of single-cell data
  • Optional:
    • Familiarity with cloud computing platforms (AWS, GCP, Azure)