Expertly Designed Preclinical & Clinical Panels
Immune profiling across species with mouse, non-human primate, and human panels
Each TokuProfile Base Panel was constructed based on extensive prior knowledge, input from our collaborative network, and experience over the course of multiple mass cytometry projects.
Mouse
Identify novel targets across congenic, syngeneic, allogeneic, and humanized mouse models
NHP
Maximize translational potential with a NHP panel that has been validated across species (Cynomolgus macaques and Rhesus macaque)
Human
Identify biomarkers of response across the immune system with our pan-immune panel, or deep profile your T cell therapy product with our T cell panel
Expertly Designed Mouse Pan-Immune Panel
The TokuProfile Mouse Pan-Immune panel includes:
- Markers to identify every major immune cell population and subsets
- Expression of key co-stimulatory and co-inhibitory molecules that regulate cell function
- Markers of recent activation and effector function
- Up to 11 open channels for customization included
-
T cells
- CD3
- Total T cells
- CD4
- CD4+ T cells
- CD8a
- CD8+ T cells
- Foxp3
- Tregs
- CD103
- Tregs
- gdTCR
- gdT cells
- CD44
- Effector/Memory
- CD62L
- Effector/Memory
- CD27
- Maturation
- CD127
- Maturation
- CD69
- Activation
- Granzyme B
- Effector
- PD-1
- Checkpoint
-
B cells
- CD19
- Total B cells
- B220 (CD45R)
- B cells
- CD27
- Naive/Memory
- CD138
- Plasmablasts, Plasma cells
- MHC-II (IA/IE)
- Antigen presentation
-
NK cells
- NK1.1
- Total NK cells
- CD49b
- Total NK cells
- CD8a
- NK cell subsets
-
Myeloid cells
- CD11b
- Total myeloid
- CD206
- Myeloid subsets
- CD64
- Monocytes, Macrophages
- F4/80
- Macrophages
- CD115
- Monocytes
- Ly6C
- Classical monocytes
- CD11c
- DCs
- CD103
- cDC1
- PDCA-1
- pDC
- MHC-II (IA/IE)
- Antigen presentation
- CD86
- Activation
- PD-L1
- Checkpoint
-
Granulocytes
Whole blood only- Ly6G
- Neutrophils
- CD11b
- Neutrophils
- Siglec-F
- Eosinophils
- CD49b
- Basophils
-
General
- CD45
- Total immune cells
- Ter119
- Erythroid cells
- DNA
- Singlets
- Live/Dead
- Viability
-
11 open channels for customization
Expertly Designed Non-Human Primate Pan-Immune Panel
The TokuProfile NHP Pan-Immune panel includes:
- Markers to identify every major immune cell population and subsets
- Expression of key co-stimulatory and co-inhibitory molecules that regulate cell function
- Markers of recent activation and effector function
- Up to 13 open channels for customization included
-
T cells
- CD3
- Total T cells
- CD4
- CD4+ T cells
- CD8a
- CD8+ T cells
- Foxp3
- Tregs
- CD25
- Treg, activation
- CD27
- Maturation
- CD28
- Co-stimulation
- CD127
- T cell subsets
- CCR7
- Naive/Memory cells
- CD45RA
- Naive/Memory cells
- gdTCR
- gdT cells
- CD161
- Th17, iNKT cells
- CD69
- Activation
- HLA-DR
- Activation
- CXCR4
- Homing
- CTLA-4
- Checkpoint
- PD-1
- Checkpoint
- CD39
- Exhaustion, tumor specific
-
B cells
- CD20
- Total B cells
- CD27
- Naive/Memory
- CD25
- Activation
- CD69
- Activation
- HLA-DR
- Antigen presentation
-
NK cells
- CD16
- NK cell subsets
- CD8a
- NK cell subsets
- NKG2a
- Inhibitory receptor
- CD161
- Cytokine responsiveness
- HLA-DR
- Proliferation
-
Myeloid cells
- CD33
- Total myeloid cells
- CD11b
- Monocytes, Macrophages
- CD11c
- Monocytes, Macrophages, DCs
- CD14
- Monocyte subsets, Macrophages
- CD56
- Monocytes
- CD16
- Monocyte subsets
- CD123
- pDCs
- CD86
- Antigen presentation
- HLA-DR
- Antigen presentation
- PD-L1
- Checkpoint
-
Granulocytes
Whole blood only- CD11b
- Neutrophils
- CD16
- Neutrophils
- CD123
- Basophils
-
General
- CD45
- Total immune cells
- KI-67
- Proliferation
- DNA, Live/Dead
- Viability
-
13 open channels for customization
Expertly Designed Human Pan-Immune Panel (Standard)
The TokuProfile Standard Human Pan-Immune panel includes:
- Markers to identify every major immune cell population and subsets
- Expression of key co-stimulatory and co-inhibitory molecules that regulate cell function
- Markers of recent activation and effector function
-
T cells
- CD3
- Total T cells
- CD4
- CD4+ T cells
- CD8a
- CD8+ T cells
- CD27
- Maturation
- CD45RA
- Naive/Memory
- CCR7 (CD197)
- Naive/Memory
- Foxp3
- Treg
- CD25
- Treg, activation
- CD127
- T cell subsets
- T-bet
- T cell subsets
- CD38
- Maturation
- CD69
- Early Activation
- HLA-DR
- Activation
- TCF1
- Stemness
- CD7
- T cell subsets
- CD56
- NKT, T cell subsets
- gdTCR
- gdT cells
- CTLA-4 (CD152)
- Checkpoint
- PD-1
- Checkpoint
- TIM-3
- Checkpoint
- TIGIT
- Checkpoint
- LAG3
- Checkpoint
- CD57
- Senescence
- KLRG-1
- Senescence
- Granzyme B
- Effector
- CD95
- Stem cell memory
- CD39
- Tumor specific
- CD28
- Co-stimulation, Maturation
- CD161
- Inhibitory Receptor
- ICOS
- Checkpoint
-
B cells
- CD19
- Total B cells
- CD25
- Activation
- CD27
- Naive/Memory
- CD38
- Naive/Memory
- HLA-DR
- Antigen presentation
- CD74
- Survival
-
NK cells
- CD56
- NK cell subsets
- CD16
- NK cell subsets
- CD8a
- NK cell subsets
- CD7
- NK cell subsets
- CD38
- Activation
- T-bet
- Maturation
- Granzyme B
- Effector
-
Myeloid cells
- CD11b
- Monocytes, macrophages
- CD11c
- Monocytes, macrophages, DCs
- CD14
- Monocyte subsets, Macrophages
- CD16
- Monocyte subsets
- CD33
- Total myeloid
- CD123
- pDC
- PD-L1
- Checkpoint ligand
- HLA-DR
- Antigen presentation
- CD86
- Activation
- CD74
- Survival
- LOX-1
- PMN-MDSCs
-
Granulocytes
Whole blood only- CD66b
- Granulocytes
- CD11b
- Neutrophils
- CD16
- Neutrophils
- CD15
- Neutrophils
- CD123
- Basophils
-
General
- CD45
- Total immune cells
- KI67
- Proliferation
- CD61
- Platelets
- CD235ab
- Erythrocytes
- DNA
- Singlets
- Live/Dead
- Viability
- IgG4
- Nivo/Pembro
Expertly Designed Human Pan-Immune Panel (Custom)
The TokuProfile Human Pan-Immune panel includes:
- Markers to identify every major immune cell population and subsets
- Expression of key co-stimulatory and co-inhibitory molecules that regulate cell function
- Markers of recent activation and effector function
- Up to 10 open channels for customization included
-
T cells
- CD3
- Total T cells
- CD4
- CD4+ T cells
- CD8a
- CD8+ T cells
- CD27
- Maturation
- CD45RA
- Naive/Memory
- CCR7 (CD197)
- Naive/Memory
- Foxp3
- Treg
- CD25
- Treg, activation
- CD127
- T cell subsets
- T-bet
- T cell subsets
- CD38
- Maturation
- HLA-DR
- Activation
- TCF1
- Stemness
- CD7
- T cell subsets
- CD56
- NKT, T cell subsets
- gdTCR
- gdT cells
- CTLA-4 (CD152)
- Checkpoint
- PD-1
- Checkpoint
- TIM-3
- Checkpoint
- TIGIT
- Checkpoint
- LAG3
- Checkpoint
-
B cells
- CD19
- Total B cells
- CD25
- Activation
- CD27
- Naive/Memory
- CD38
- Naive/Memory
- HLA-DR
- Antigen presentation
-
NK cells
- CD56
- NK cell subsets
- CD16
- NK cell subsets
- CD8a
- NK cell subsets
- CD7
- NK cell subsets
- CD38
- Activation
- T-bet
- Maturation
-
Myeloid cells
- CD11b
- Monocytes, macrophages
- CD11c
- Monocytes, macrophages, DCs
- CD14
- Monocyte subsets, Macrophages
- CD16
- Monocyte subsets
- CD33
- Total myeloid
- CD123
- pDC
- PD-L1
- Checkpoint ligand
- HLA-DR
- Antigen presentation
-
Granulocytes
Whole blood only- CD66b
- Granulocytes
- CD11b
- Neutrophils
- CD16
- Neutrophils
- CD123
- Basophils
-
General
- CD45
- Total immune cells
- KI67
- Proliferation
- CD61
- Platelets
- CD235ab
- Erythrocytes
- DNA
- Singlets
- Live/Dead
- Viability
-
10 open channels for customization
Optional add-on packages
Simplify your panel customization with these add-on packages at no additional cost.
Each package is expertly designed to expand your panel’s tissue-specific immune cell identification:
- Circulating granulocytes in whole blood
- Hematopoietic stem cells in bone marrow
-
Whole Blood add-on
- FcERI
- Basophils, Mast cells
- c-Kit
- Mast cells
- CD15
- Neutrophils
- Siglec-8
- Eosinophils
- LOX-1
- PMN-MDSCs
-
5 remaining channels for customization
-
Bone Marrow add-on
- FcERI
- Mast cells
- c-Kit
- HSCs, Mast cells
- CD34
- HSCs
- CD90
- HSCs
- CD49f
- HSCs
-
6 remaining channels for customization
Expertly Designed Human T Cell Panel
The TokuProfile Human T cell panel includes:
- Markers to identify every major T cell subset
- Expression of key checkpoint molecules that regulate cell function
- Markers of recent activation and effector function
- Up to 9 open channels for customization included
-
T cell subsets
- CD3
- Total T cells
- CD4
- CD4+ T cells
- CD8a
- CD8+ T cells
- Foxp3
- Tregs
- gdTCR
- gdT cells
- CD27
- Naive/Memory
- CD45RA
- Naive/Memory
- CCR7
- Naive/Memory
- CD127
- Treg, memory
- CD25
- Treg
- Tbet
- Th1
- CD56
- NKT cells
- CD95
- Stem cell memory
- CD39
- Tumor specific
-
Activation / Maturation
- CD25
- Activation
- CD28
- Co-stimulation, maturation
- CD69
- Early activation
- Granzyme B
- Effector
- KI67
- Proliferation
- HLA-DR
- Activation
- CD27
- Maturation
- CD38
- Activation, maturation
-
Checkpoints
- CTLA-4 (CD152)
- Checkpoint
- PD-1 (CD279)
- Checkpoint
- TIM-3
- Checkpoint
- CD57
- Senescence
- KLRG-1
- Senescence
- TIGIT
- Checkpoint
- CD161
- Inhibitory receptor
- PD-L1 (CD274)
- Checkpoint
- ICOS
- Checkpoint
- LAG3
- Checkpoint
- CD39
- Exhaustion
- CD95 (Fas)
- Cell death
-
Non-T cells
- CD66b
- Granulocytes
- CD19
- B cells
- CD14
- Monocytes, macrophages
-
General
- CD45
- Total immune cells
- Mouse CD45
- Humanized mice
- DNA
- Singlets
- Live/Dead
- Viability
-
9 open channels for customization
Technical Whitepaper
Teiko Bio’s Panel and Custom Antibody Validation ProcessFill out the form below to download the full technical whitepaper.