Teiko.bio

Expertly Designed Preclinical & Clinical Panels

Immune profiling across species with mouse, non-human primate, and human panels

Each TokuProfile Base Panel was constructed based on extensive prior knowledge, input from our collaborative network, and experience over the course of multiple mass cytometry projects.

Mouse

Identify novel targets across congenic, syngeneic, allogeneic, and humanized mouse models

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NHP

Maximize translational potential with a NHP panel that has been validated across species (Cynomolgus macaques and Rhesus macaque)

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Human

Identify biomarkers of response across the immune system with our pan-immune panel, or deep profile your T cell therapy product with our T cell panel

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Expertly Designed Mouse Pan-Immune Panel

The TokuProfile Mouse Pan-Immune panel includes:

  • Markers to identify every major immune cell population and subsets
  • Expression of key co-stimulatory and co-inhibitory molecules that regulate cell function
  • Markers of recent activation and effector function
  • Up to 11 open channels for customization included
Customize your mouse panel

  • T cells

    CD3
    Total T cells
    CD4
    CD4+ T cells
    CD8a
    CD8+ T cells
    Foxp3
    Tregs
    CD103
    Tregs
    gdTCR
    gdT cells
    CD44
    Effector/Memory
    CD62L
    Effector/Memory
    CD27
    Maturation
    CD127
    Maturation
    CD69
    Activation
    Granzyme B
    Effector
    PD-1
    Checkpoint

  • B cells

    CD19
    Total B cells
    B220 (CD45R)
    B cells
    CD27
    Naive/Memory
    CD138
    Plasmablasts, Plasma cells
    MHC-II (IA/IE)
    Antigen presentation

  • NK cells

    NK1.1
    Total NK cells
    CD49b
    Total NK cells
    CD8a
    NK cell subsets

  • Myeloid cells

    CD11b
    Total myeloid
    CD206
    Myeloid subsets
    CD64
    Monocytes, Macrophages
    F4/80
    Macrophages
    CD115
    Monocytes
    Ly6C
    Classical monocytes
    CD11c
    DCs
    CD103
    cDC1
    PDCA-1
    pDC
    MHC-II (IA/IE)
    Antigen presentation
    CD86
    Activation
    PD-L1
    Checkpoint

  • Granulocytes

    Whole blood only
    Ly6G
    Neutrophils
    CD11b
    Neutrophils
    Siglec-F
    Eosinophils
    CD49b
    Basophils

  • General

    CD45
    Total immune cells
    Ter119
    Erythroid cells
    DNA
    Singlets
    Live/Dead
    Viability

  • 11 open channels for customization

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Expertly Designed Non-Human Primate Pan-Immune Panel

The TokuProfile NHP Pan-Immune panel includes:

  • Markers to identify every major immune cell population and subsets
  • Expression of key co-stimulatory and co-inhibitory molecules that regulate cell function
  • Markers of recent activation and effector function
  • Up to 13 open channels for customization included
Customize your NHP panel

  • T cells

    CD3
    Total T cells
    CD4
    CD4+ T cells
    CD8a
    CD8+ T cells
    Foxp3
    Tregs
    CD25
    Treg, activation
    CD27
    Maturation
    CD28
    Co-stimulation
    CD127
    T cell subsets
    CCR7
    Naive/Memory cells
    CD45RA
    Naive/Memory cells
    gdTCR
    gdT cells
    CD161
    Th17, iNKT cells
    CD69
    Activation
    HLA-DR
    Activation
    CXCR4
    Homing
    CTLA-4
    Checkpoint
    PD-1
    Checkpoint
    CD39
    Exhaustion, tumor specific

  • B cells

    CD20
    Total B cells
    CD27
    Naive/Memory
    CD25
    Activation
    CD69
    Activation
    HLA-DR
    Antigen presentation

  • NK cells

    CD16
    NK cell subsets
    CD8a
    NK cell subsets
    NKG2a
    Inhibitory receptor
    CD161
    Cytokine responsiveness
    HLA-DR
    Proliferation

  • Myeloid cells

    CD33
    Total myeloid cells
    CD11b
    Monocytes, Macrophages
    CD11c
    Monocytes, Macrophages, DCs
    CD14
    Monocyte subsets, Macrophages
    CD56
    Monocytes
    CD16
    Monocyte subsets
    CD123
    pDCs
    CD86
    Antigen presentation
    HLA-DR
    Antigen presentation
    PD-L1
    Checkpoint

  • Granulocytes

    Whole blood only
    CD11b
    Neutrophils
    CD16
    Neutrophils
    CD123
    Basophils

  • General

    CD45
    Total immune cells
    KI-67
    Proliferation
    DNA, Live/Dead
    Viability

  • 13 open channels for customization

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Expertly Designed Human Pan-Immune Panel

The TokuProfile Human Pan-Immune panel includes:

  • Markers to identify every major immune cell population and subsets
  • Expression of key co-stimulatory and co-inhibitory molecules that regulate cell function
  • Markers of recent activation and effector function
  • Up to 12 open channels for customization included
Customize your human panel

  • T cells

    CD3
    Total T cells
    CD4
    CD4+ T cells
    CD8a
    CD8+ T cells
    CD25
    Treg, activation
    CD27
    Maturation
    CD38
    Maturation
    CD45RA
    Naive/Memory
    CD45RO
    Naive/Memory
    CD56
    NKT, T cell subsets
    CD127
    T cell subsets
    CTLA-4 (CD152)
    Checkpoint
    CCR7 (CD197)
    Naive/Memory
    PD-1
    Checkpoint
    Foxp3
    Treg
    HLA-DR
    Activation
    T-bet
    T cell subsets
    gdTCR
    gdT cells
    TIM-3
    Checkpoint
    TCRVa24-Ja18
    iNKT cells

  • B cells

    CD19
    Total B cells
    CD25
    Activation
    CD27
    Naive/Memory
    CD38
    Naive/Memory
    HLA-DR
    Antigen presentation

  • NK cells

    CD8a
    NK cell subsets
    CD16
    NK cell subsets
    CD38
    Activation
    CD56
    NK cell subsets
    T-bet
    Maturation

  • Myeloid cells

    CD11b
    Monocytes, macrophages
    CD11c
    Monocytes, macrophages, DCs
    CD14
    Monocyte subsets, Macrophages
    CD16
    Monocyte subsets
    CD33
    Total myeloid
    CD123
    pDC
    PD-L1
    Checkpoint ligand
    FceR1a
    pDCs, DCs
    HLA-DR
    Antigen presentation

  • Granulocytes

    Whole blood only
    CD11b
    Neutrophils
    CD16
    Neutrophils
    CD117
    Mast cells
    CD123
    Basophils
    FceR1a
    Basophils

  • General

    CD45
    Total immune cells
    CD66b
    Granulocytes
    KI67
    Proliferation
    DNA
    Singlets
    Live/Dead
    Viability

  • 12 open channels for customization

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Expertly Designed Human T Cell Panel

The TokuProfile Human T cell panel includes:

  • Markers to identify every major T cell subset
  • Expression of key checkpoint molecules that regulate cell function
  • Markers of recent activation and effector function
  • Up to 9 open channels for customization included
Customize your T cell panel

  • T cell subsets

    CD3
    Total T cells
    CD4
    CD4+ T cells
    CD8a
    CD8+ T cells
    Foxp3
    Tregs
    gdTCR
    gdT cells
    CD27
    Naive/Memory
    CD45RA
    Naive/Memory
    CCR7
    Naive/Memory
    CD127
    Treg, memory
    CD25
    Treg
    Tbet
    Th1
    CD56
    NKT cells
    CD95
    Stem cell memory
    CD39
    Tumor specific

  • Activation / Maturation

    CD25
    Activation
    CD28
    Co-stimulation, maturation
    CD69
    Early activation
    Granzyme B
    Effector
    KI67
    Proliferation
    HLA-DR
    Activation
    CD27
    Maturation
    CD38
    Activation, maturation

  • Checkpoints

    CTLA-4 (CD152)
    Checkpoint
    PD-1 (CD279)
    Checkpoint
    TIM-3
    Checkpoint
    CD57
    Senescence
    KLRG-1
    Senescence
    TIGIT
    Checkpoint
    CD161
    Inhibitory receptor
    PD-L1 (CD274)
    Checkpoint
    ICOS
    Checkpoint
    LAG3
    Checkpoint
    CD39
    Exhaustion
    CD95 (Fas)
    Cell death

  • Non-T cells

    CD66b
    Granulocytes
    CD19
    B cells
    CD14
    Monocytes, macrophages

  • General

    CD45
    Total immune cells
    Mouse CD45
    Humanized mice
    DNA
    Singlets
    Live/Dead
    Viability

  • 9 open channels for customization

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Looking for preliminary data? Give our Starter Package a try.

$10,000 Flat Rate

As a first-time customer, you can analyze 6 blood samples to help guide the next step of your research or therapeutic pipeline.

To build your Starter Package:

  • Choose any one of our TokuProfile base panels above
  • Download the full panel spreadsheet by clicking “Customize your panel”
  • Select up to 4 additional markers from our wide selection of in-house antibodies available within open channels