Cell Therapy Development
The first 44-marker high-resolution mass cytometry panels dedicated to accelerating development of T and NK cell therapies.
Source identification
Select ideal donor and source material based with profiling of over 1T cellular marker combinations
Process optimization
Increase yield, shorten turnaround, and optimize final cellular product with data-driven insights at every stage of the process
Clinical profiling
Track and profile cell therapy product in vivo to identify early phenotypic markers of response
Let data drive your development pipeline
Improve cell therapy development and manufacturing with high-resolution data profiling how each stage of therapeutic development impacts function of final product
Expertly Designed Human T Cell Panel
The TokuProfile Human T cell panel was constructed based on extensive prior knowledge, input from our collaborative network, and experience over the course of dozens of unique mass cytometry projects. The panel includes:
- Markers to identify every major T cell subset
- Expression of key checkpoint molecules that regulate cell function
- Markers of recent activation and effector function
- Up to 9 open channels for customization included
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T cell subsets
- CD3
- Total T cells
- CD4
- CD4+ T cells
- CD8a
- CD8+ T cells
- Foxp3
- Tregs
- gdTCR
- gdT cells
- CD27
- Naive/Memory
- CD45RA
- Naive/Memory
- CCR7
- Naive/Memory
- CD127
- Treg, memory
- CD25
- Treg
- Tbet
- Th1
- CD56
- NKT cells
- CD95
- Stem cell memory
- CD39
- Tumor specific
-
Activation / Maturation
- CD25
- Activation
- CD28
- Co-stimulation, maturation
- CD69
- Early activation
- Granzyme B
- Effector
- KI67
- Proliferation
- HLA-DR
- Activation
- CD27
- Maturation
- CD38
- Activation, maturation
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Checkpoints
- CTLA-4 (CD152)
- Checkpoint
- PD-1 (CD279)
- Checkpoint
- TIM-3
- Checkpoint
- CD57
- Senescence
- KLRG-1
- Senescence
- TIGIT
- Checkpoint
- CD161
- Inhibitory receptor
- PD-L1 (CD274)
- Checkpoint
- ICOS
- Checkpoint
- LAG3
- Checkpoint
- CD39
- Exhaustion
- CD95 (Fas)
- Cell death
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Non-T cells
- CD66b
- Granulocytes
- CD19
- B cells
- CD14
- Monocytes, macrophages
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General
- CD45
- Total immune cells
- Mouse CD45
- Humanized mice
- DNA
- Singlets
- Live/Dead
- Viability
-
9 open channels for customization
Deep profiling of NK cell receptor expression
Teiko is developing the first 44-marker mass cytometry panel focused entirely on NK cell receptor profiling for cell therapy development. Profile markers of NK maturation and activation plus over 20 activating and inhibitory receptors per cell. Panel includes up to 5 open channels to track product-specific markers of interest.