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Publications from a variety of academic and industry groups, including work co-authored by Teiko scientists, demonstrate the critical role that peripheral blood plays in the treatment of cancer
Identifying predictors of survival in patients with leukemia using single-cell mass cytometry and machine learning
Kleftogiannis et al. developed a machine learning framework using mass cytometry data from 45 leukemia patients and identified predictive biomarkers of survival
Deep analysis of the peripheral immune system in IBD reveals new insight in disease subtyping and response to monotherapy or combination therapy
Kosoy et al. profiled immune composition of nearly 1200 patients with IBD and over 300 controls using mass cytometry and identified key immune subsets target by combination therapy.
Distinct injury responsive regulatory T cells identified by multi-dimensional phenotyping
In Guo et al., the team used mass cytometry in combination with RNA and TCR sequencing to validate two unique clusters of regulatory T cells (Treg) that respond differently to injury.
Deep immune profiling reveals targetable mechanisms of immune evasion in immune checkpoint inhibitor-refractory glioblastoma
The team Simonds, Lu, & Badillo et al. used mass cytometry determine why glioblastoma, the most common malignant brain tumor, is also the most resistant to immunotherapy.