.png)
Flexible Immune Profiling That Works on Your Timeline
TokuFocus
Start with a 10-marker TBNK panel and unlock the full panel data whenever you're ready, all from a single sample.
1
2
3
Why Teams Choose TokuFocus
See How TokuFocus Solves Trial Challenges
Not ready to commit to a full cytometry panel before seeing a signal? We get it, see how TokuFocus can help.
Phase I Timeline
In a first-in-human trial, early efficacy is observed. Three out of ten patients respond, but the limited TBNK panel offers no clues as to why. The team faces a critical decision point: move forward without understanding the full picture of the biology or find a way to uncover what differentiates responders from non-responders.
With TokuFocus, the full 41-marker panel had already been run, so the answer was already in hand. With a simple unlock, the team uncovers key immune differences and gains the clarity needed to confidently design their next phase.
First-in-human dosing begins. Fresh blood collected and run on 10-marker TBNK panel.
Trial begins with TokuKit. Blood stabilized and full 41-marker mass cytometry panel is run. Only TBNKM subset is unlocked ($1,000/sample).
Clinical team sees response in 3 of 10 patients. No insights yet from basic immune data.
Same responders emerge. TBNK panel doesn't differentiate, but full panel data is already archived.
Internal team asks: Why are these 3 responding? TBNK shows no clear difference.
Internal team asks the same. Plans to unlock deeper immune data post-analysis.
What happens next?
Your team wants to explore mechanism. Best case, there are some additional samples banked for for deeper profiling. Otherwise, it's time to start from square one and recollect.
Either way, you're left:
- Waiting months until you get a readout.
- Spending double what you anticipated to recollect, process, and analyze the samples.
- Without the ability to compare results between studies; we’ve all seen the reproducibility issues that come with your average big-box CRO.
Your team wants to explore mechanism. They reach out to Teiko to unlock the data from the full 41-marker panel.
With the unlock, you'll:
- Get your data within two weeks.
- Only spend $900 per sample. No hidden costs that may come with recollecting, shipping, or processing the new samples.
- Have results that are directly comparable to the previous TBNKM data, deepening your understanding of your drug's mechanism of action.
Phase II/III Timeline
A sponsor wraps up a promising Phase 2 trial. The FDA asks for deeper immune data to support the mechanism, but only a basic panel was collected. The team scrambles to recollect samples, but patients are off treatment, key timepoints are lost, and IRB approvals slow everything down.
As the team prepares for a Phase 2 milestone meeting or Phase 3 expansion, the missing data puts the program at risk. With TokuFocus, the full 41-marker panel is already processed on every sample. When more is needed, the data is ready without recollection or delay.
Phase 2/3 starts with a 10-marker TBNK panel. No additional markers are captured.
Phase 2/3 starts with TokuFocus. Full 41-marker panel is processed up front, but only TBNKM data is unlocked.
Initial efficacy is observed in a subset of patients. Team prepares for FDA engagement.
Same result — early data looks promising, and TBNKM readouts are available for review.
FDA requests deeper immune profiling to support mechanism of action and biomarker strategy.
FDA makes same request. Team already has full panel data banked for all samples.
What happens next?
The FDA asks for deeper immune data. Your team only ran a TBNK panel, and the clock is ticking.
In the meantime, your team is stuck:
- Waiting months to scrape together data.
- Spending more than expected on logistical challenges and analysis.
- Planning an additional study with new patients.
Your team already has the full dataset banked on a 25- or 41- marker panel. They reach out to unlock the panel for $900/sample.
With the unlock, your team will:
- Get high-dimensional data within two weeks.
- Avoid recollecting, reprocessing, or dealing with missed timepoints.
- Confidently advance submission with a complete immune profile ready for review
Start with a focused panel, expand when you're ready.
Swipe to see the immune cell populations profiled in each panel.
.svg)
Pricing
Pay for the data you want, when you want it.
TokuFocus
Unlock data on your timeline
- 20 sample minimum per batch with mass cytometry
- 50 sample minimum per batch with spectral flow cytometry
- Unlock the full panel within a year of original data delivery
Focused TBNKM Panel
Access to gated cell populations and functional subsets from the 10-marker TBNKM panel- Visualize gated results and statistical analysis on Dashboard
- Access data tables and sample and gating quality control reports
- Option for software-based unlock of all cell populations within 6 months of processing
Remaining Panel Data
- Everything from the focused panel, plus the data from all populations and functional subsets on full panel
- Export FCS and GatingML files from Dashboard
- Two consulting hours
- Upgrade to premier analysis to uncover novel cell populations with unsupervised clustering
Ready to get started with TokuFocus?
Frequently Asked Questions
Got a question? We've got you covered.
Can I pick the subset?
Something we're thinking about, but not with this release. Here are the markers included in our basic TBNK panels:
Is unsupervised analysis available on the focused panel?
Unsupervised analysis isn't included in the focused 10-marker panel, but it's available whenever you're ready to dive deeper. Once you upgrade to the full panel, unsupervised analysis is included to help you explore the full complexity of your data.
Can I cherry pick which samples to upgrade? That is, if I send you 50 samples, can I upgrade 30?
Upgrades are generally done in full batches, but we’re open to discussing alternative approaches if your study requires more flexibility. Contact our team to explore what might work best for you.
Will I see the full gating tree before upgrading?
Yes. The dashboard will display the full gating tree, but any locked populations will appear greyed out until you upgrade.
What if I want to run multiple cohorts?
Absolutely. We can support multiple cohorts, but keep in mind:
- Spectral Flow: Minimum of 50 specimens per cohort
- Mass Cytometry: Minimum of 20 specimens per cohort
Can I do this on a custom panel?
This is handled on a case-by-case basis. TokuFocus was built for our off-the-shelf panels, but we’re open to discussing custom panel options depending on your study needs. Reach out to our team to explore what’s possible.
